মঙ্গলবার, ২৬ জুন, ২০১২

Exercise, even mild physical activity, may reduce breast cancer risk

Exercise, even mild physical activity, may reduce breast cancer risk [ Back to EurekAlert! ] Public release date: 25-Jun-2012
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Contact: Amy Molnar
healthnews@wiley.com
Wiley-Blackwell

A new analysis has found that physical activity either mild or intense and before or after menopause may reduce breast cancer risk, but substantial weight gain may negate these benefits. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings indicate that women can reduce their breast cancer risk by exercising and maintaining their weight.

While studies have shown that physical activity reduces breast cancer risk, many questions remain. For example, how often, how long, and how intense does physical activity have to be to provide benefits? Also, do women with all body types experience a reduced risk when they exercise, and does exercise reduce the risk of all types of breast cancer?

To investigate, Lauren McCullough, of the University of North Carolina Gillings School of Global Public Health in Chapel Hill, and her colleagues looked for a link between recreational physical activity, done at different time points in life, and the risk of developing breast cancer.

The study included 1,504 women with breast cancer (233 noninvasive and 1,271 invasive) and 1,555 women without breast cancer who were 20 to 98 years old and were part of the Long Island Breast Cancer Study Project, an investigation of possible environmental causes of breast cancer.

Women who exercised either during their reproductive or postmenopausal years had a reduced risk of developing breast cancer. Women who exercised 10 to 19 hours per week experienced the greatest benefit with an approximate 30% reduced risk. Risk reductions were observed at all levels of intensity, and exercise seemed to preferentially reduce the risk of hormone receptor positive breast cancer (ER or PR positive), which is the most commonly diagnosed tumor type among American women.

"The observation of a reduced risk of breast cancer for women who engaged in exercise after menopause is particularly encouraging given the late age of onset for breast cancer," said McCullough.

When the researchers looked at the joint effects of physical activity, weight gain, and body size, they found that even active women who gained a significant amount of weight particularly after menopause had an increased risk of developing breast cancer, indicating that weight gain can eliminate the beneficial effects of exercise on breast cancer risk.

###



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Exercise, even mild physical activity, may reduce breast cancer risk [ Back to EurekAlert! ] Public release date: 25-Jun-2012
[ | E-mail | Share Share ]

Contact: Amy Molnar
healthnews@wiley.com
Wiley-Blackwell

A new analysis has found that physical activity either mild or intense and before or after menopause may reduce breast cancer risk, but substantial weight gain may negate these benefits. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings indicate that women can reduce their breast cancer risk by exercising and maintaining their weight.

While studies have shown that physical activity reduces breast cancer risk, many questions remain. For example, how often, how long, and how intense does physical activity have to be to provide benefits? Also, do women with all body types experience a reduced risk when they exercise, and does exercise reduce the risk of all types of breast cancer?

To investigate, Lauren McCullough, of the University of North Carolina Gillings School of Global Public Health in Chapel Hill, and her colleagues looked for a link between recreational physical activity, done at different time points in life, and the risk of developing breast cancer.

The study included 1,504 women with breast cancer (233 noninvasive and 1,271 invasive) and 1,555 women without breast cancer who were 20 to 98 years old and were part of the Long Island Breast Cancer Study Project, an investigation of possible environmental causes of breast cancer.

Women who exercised either during their reproductive or postmenopausal years had a reduced risk of developing breast cancer. Women who exercised 10 to 19 hours per week experienced the greatest benefit with an approximate 30% reduced risk. Risk reductions were observed at all levels of intensity, and exercise seemed to preferentially reduce the risk of hormone receptor positive breast cancer (ER or PR positive), which is the most commonly diagnosed tumor type among American women.

"The observation of a reduced risk of breast cancer for women who engaged in exercise after menopause is particularly encouraging given the late age of onset for breast cancer," said McCullough.

When the researchers looked at the joint effects of physical activity, weight gain, and body size, they found that even active women who gained a significant amount of weight particularly after menopause had an increased risk of developing breast cancer, indicating that weight gain can eliminate the beneficial effects of exercise on breast cancer risk.

###



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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রবিবার, ২৪ জুন, ২০১২

'Brave' hits bull's-eye at the box office

By Pamela McClintock, The Hollywood Reporter

Pixar

"Brave" earned $66.7 million on its opening weekend.

Fears that a female heroine would slow down "Brave" proved unfounded as the animated tentpole opened to a whopping $66.7 million at the domestic box office -- the fifth best debut of all time for a Pixar title.

PHOTOS: From 'Toy Story' to 'Brave': Your Essential Guide to Pixar's Movies

"Brave,"?continuing Pixar's unblemished record of opening all of its movies to No. 1, also scored the second highest June opening for an animated pic after Pixar's "Toy Story 3" ($110.3 million). Overseas, the Pixar and Disney title debuted to $13.5 million in 10 markets.

The 3D event pic -- receiving an A CinemaScore in North America -- marks Pixar's 13th film and is the first movie in the company's history to feature a female lead. "Brave" did skew female (57 percent), but got plenty of male attention.

"You have to draw men and boys as well to see this number," Disney executive president of worldwide distribution Dave Hollis said. "The themes in the movie -- bravery, fighting for your fate -- transcend gender."

Hollis credited Pixar/Disney animation chief John Lasseter, producer Katherine Sarafian and directors Mark Andrews and Brenda Chapman for delivering an "enveloping experience" that drew both families (66 percent) and adults.

One troubling statistic: 3D revenues only made up 34 percent of "Brave's"?opening gross, furthering worries that families find the upcharge for a 3D ticket too expensive.

Still, family product ruled the box office all the way around. DreamWorks Animation and Paramount holdover "Madagascar 3: Europe's Most Wanted" fell to No. 2 in its third weekend with an estimated $20.2 million for a domestic cume of roughly?$157.6 million ("Madagascar 3"?opened to $60.1 million).?

Animation also ruled overseas, where "Madagascar 3" stayed at No. 1 for the third weekend in a row, grossing $30.1 million from 44 markets to race past the $200 million mark. The pic has now earned $208.4 million internationally for an impressive worldwide total of $366 million.

Managing only a third-place domestic finish was 20th Century Fox's 3D genre epic "Abraham Lincoln: Vampire Hunter." The R-rated film, playing like a horror title, grossed a soft $16.5 million in its opening. Fox had predicted a debut in the $15 million range -- considering there are no big stars in the film --? but box office observers believed it could get to $20 million.

Directed by Timur Bekmambetov and featuring Tim Burton in the producer's seat, "Abraham Lincoln" received a C+ CinemaScore. The pic's cast is led by Benjamin Walker.

"Abraham Lincoln,"?costing $68 million to produce, features the storied U.S. president as a vampire hunter and is based on the novel by?Seth Grahame-Smith, who also wrote the adapted screenplay. The film is an important test for the "mash-up" genre, with Lionsgate queued up to make the film adaptation of Grahame-Smith's book "Pride and Prejudice and Zombies."

Fox believes "Abraham Lincoln,"?which skewed male, will have good legs.

"Audiences will continue to seek out Timur's daring and brilliant vision of 'Abraham Lincoln,' " Fox's incoming president of domestic distribution Chris Aronson said.

The news wasn't good for Steve Carell-Keira Knightley indie pic "Seeking a Friend for the End of the World," which debuted to $3.8 million from 1,625 locations. The Focus Features title, directed and written by Lorene Scafaria, came in No. 10, just ahead of fellow Focus pic "Moonrise Kingdom," which grossed a pleasing $3.4 million from only 395 theaters for a pleasing cume of $11.6 million.

"It's disappointing. The right people turned up to see "Seeking a Friend," but they didn't come in volume," Focus president of distribution Jack Foley said.

At the specialty box office, Woody Allen's new entry "To Rome With Love" got off to a strong start, grossing $379,371 from five theaters for a sizeable location average of $75,874 -- easily the best of the weekend. Sony Pictures Classics, which distributed Allen's box office hit "Midnight in Paris," is once again handling domestic distribution duties for the filmmaker.

Elsewhere, New Line and Warner Bros.' troubled musical "Rock of Ages" fell to No. 6 in its second weekend, grossing $8 million for a 10-day domestic cume of $28.8 million. Adam Sandler's comedy "That's My Boy," likewise troubled, fell to No. 7 in its second outing, grossing $7.9 million for a 10-day total of $28.2 million.

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Issa: President's executive privilege claims 'simply wrong'

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Facebook ? Employers may review unprotected profiles

A good security awareness article regarding the need to secure profile information and be careful with information that is posted.

Facebook ? Employers may review unprotected profiles
http://www.securitynewsdaily.com/2001-personal-secrets-facebook.html

QUOTE:? Whether you?re looking for a job, or already have one, there?s one thing you can be sure of: It?s not only your Facebook ?friends? who are looking at your social media profile? Those doing the hiring freely admit they search potential job candidates? Facebook profiles. If you think your current co-workers, employees or boss aren?t stopping in for an undetected peek at your profile every so often, you?re deluding yourself.???So what?? you think. ?There?s nothing on my Facebook profile that I?m ashamed of.? Are you sure? You might be surprised how much of what?s on your Facebook page is inappropriate for work.

Here are just a few of the things you?re revealing about yourself that you might not have considered.

1. Your age. Even if you didn?t use your real age when you signed up for Facebook, it?s pretty easy to figure out.

2. Your political beliefs. Anyone with a little common sense knows that talking politics at work is a bad idea, but anyone checking out your Facebook page could probably pretty easily figure out where you stand.

3. Your personal life. What?s the point of putting on a power suit for work if everyone in your office can see photos of you in your pajamas on Christmas morning on your Facebook page?

4. Your childhood. those photos your mom keeps posting of you as a kid in the bathtub are cute, too. While they?re not exactly blackmail material, there?s little doubt they?ll help undermine your efforts to command much respect around the office.

5. Your religious beliefs. What you believe is no one else?s business. But that doesn?t mean they won?t hold it against you.

6. Your work alliances. Even if you think you?re good at playing office politics, odds are your Facebook page tells the real truth about who you like and who you don?t.

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Colorado town evacuated as fire grows

COLORADO SPRINGS, Colo. (AP) ? A wildfire near Colorado Springs erupted and grew out of control to more than 3 square miles over the weekend, prompting the evacuation of a popular vacation town and the closure of nearby highways Sunday.

At least 11,000 residents of the town of Manitou Springs and nearby communities of Cascade, Chipita Park and Green Mountain Falls were ordered to leave Saturday or early Sunday. The fire quickly grew to more than 2,000 acres amid tinder dry conditions, gusty winds and temperatures that reached into the 90s.

Officials didn't immediately have a count on those evacuated from campgrounds, inns, rental cabins and other vacation properties that were emptied, but an evacuation center set up at a high school housed mostly tourists.

They included Mark Stein of Morristown, N.J., whose family arrived after midnight Sunday at their Manitou Springs hotel for a week of whitewater rafting and sightseeing.

"We were sleeping for 15 minutes when they started knocking on the door ? a day from hell," Stein said of the day of travel. With his wife and 12-year-old son, Stein spent the first night of his vacation setting up cots for more than 100 evacuees who slept at the school.

"I think it's the best vacation ever. This is what the real world is about. There's a lot of people that need help," Stein said.

The fire also prompted evacuations for the west side of Colorado Springs and in the towns of Cascade and Ute Pass, but no structures have been destroyed and no buildings were under immediate threat.

The Garden of the Gods park, which has dramatic red rock formations, was also closed. Pikes Peak, the most-visited high-altitude peak in the nation that inspired the song "America The Beautiful," was completely obscured by gray smoke.

Officials closed traffic into Manitou Springs, a vacation town at the base of Pikes Peak, and shut down the Pikes Peak Highway, which goes to the top of the mountain.

Hundreds of other residents were under voluntary evacuation orders and were packing up, the Colorado Springs Gazette reported Saturday.

About 350 firefighters were dispatched to the blaze, with more in the way, said Rob Deyerberg of the Fairmount Fire Protection District. But the fire was still zero percent contained. A plume of smoke from the foothills near Pikes Peak thickened and turned from light gray to brown.

Conditions remained dry and windy Sunday, and the National Weather Service said temperatures were forecast to be close to 100 degrees throughout much of the state.

Gov. John Hickenlooper said two C-130 military transport planes from Peterson Air Force Base in Colorado Springs would assist fighting the fire on Monday. With eight separate wildfire burning across Colorado, Hickenlooper said half the nation's firefighting resources were in the state but that it will take time to put out the blazes.

"People recognize this going to take a big push," Hickenlooper said.

Colorado and other parts of the Southwest have become a tinderbox for wildfires as the region faces extremely dry or prolonged drought conditions. At least seven were burning across the state, where officials have been challenged by one of the most severe fire seasons in recent memory.

The weather also helped fuel another blaze that sparked Saturday and destroyed 21 structures near the mountain community of Estes Park. Investigators were determining whether it started in a cabin or as a wildfire before moving toward the homes, according to the Denver Post.

"Even though we lost 21 (structures), which is a huge tragedy, we saved many homes because of firefighters' efforts," Estes Park Fire Chief Scott Dorman told evacuees.

A separate fire continued burning near Fort Collins, scorching more than 118 square miles and destroying at least 191 homes.

Elsewhere in the West, firefighters made progress against wildfires in Utah, New Mexico and California.

? In Utah, about 2,300 residents were allowed to return to their homes Saturday after officials determined a wildfire no longer posed a threat to homes near Saratoga Springs and Eagle Mountain. Officials believe that fire was started Thursday by target shooters. A second major fire has burned 16,500-acres of high desert near the central Utah town of Delta.

? In California, a wildfire about 60 miles north of Los Angeles triggered evacuations of campgrounds around an off-road recreation area on Saturday. Ventura County fire officials said the fire has blackened at least 400 acres in the Hungry Valley State Vehicular Recreation Area, along the Interstate 5 corridor in Gorman.

? In New Mexico, a lightning-caused wildfire that destroyed 242 homes and businesses is 90 percent contained after heavy rain helped crews Friday. The 69-square-mile fire near Ruidoso began June 4. Meanwhile, the largest wildfire in state history was 87 percent contained. It has burned more than 464 square miles after two blazes merged on May 16.

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শনিবার, ২৩ জুন, ২০১২

Jury to begin hearing Texas bomb plot trial

This undated photo provided by the Randall County, Texas, Sheriff's Department shows Khalid Ali-M Aldawsari. A jury was selected Thursday, June 21, 2012, for the trial of the Saudi man who is accused of gathering bomb components with the intention of targeting sites across the United States, including the home of former President George W. Bush. (AP Photo/Randall County Sheriff)

This undated photo provided by the Randall County, Texas, Sheriff's Department shows Khalid Ali-M Aldawsari. A jury was selected Thursday, June 21, 2012, for the trial of the Saudi man who is accused of gathering bomb components with the intention of targeting sites across the United States, including the home of former President George W. Bush. (AP Photo/Randall County Sheriff)

FILE - In this Feb. 25, 2011, file photo, Khalid Ali-M Aldawsari is escorted to court in Lubbock, Texas. A jury was selected Thursday, June 21, 2012, for the trial of the Saudi man who is accused of gathering bomb components with the intention of targeting sites across the United States, including the home of former President George W. Bush.(AP Photo/Lubbock Avalanche-Journal, Zach Long, File)

A security officer patrols around the Federal Courthouse in Amarillo, Texas Thursday June 21, 2012 as jury selection began for a Saudi man, Khalid Ali-M Aldawsari, accused of gathering bomb making supplies in his Lubbock apartment. (AP Photo/The Amarillo Globe News, Michael Schumacher) MANDATORY CREDIT; MAGS OUT; TV OUT; AP MEMBERS ONLY

(AP) ? Federal prosecutors Friday will begin presenting their case against a Saudi man accused of gathering bomb components in his West Texas apartment with the goal of targeting sites across the United States.

Khalid Ali-M Aldawsari, 22, faces up to life in prison and a $250,000 fine if convicted of attempted use of a weapon of mass destruction. Targets he allegedly researched included the Dallas home of former President George W. Bush, dams and nuclear plants.

Opening statements are set for Friday morning. Aldawsari, a former Texas Tech University chemical engineering student who has pleaded not guilty, will then watch as prosecutors begin to present as many as 34 witnesses and 429 exhibits to try to prove their case to a jury in federal court in Amarillo, where the trial was moved for reasons not made public.

A jury of eight women and six men was selected Thursday; the panel includes two alternates.

Court records show Aldawsari's attorneys plan to use an insanity defense.

Federal agents secretly searched Aldawsari's apartment in Lubbock, Texas, twice in February 2011 and say they found almost everything needed to build a bomb, including chemicals, beakers, flasks, wiring, a hazmat suit and clocks, which he had bought online in the previous months.

Authorities say they were tipped to Aldawsari's online purchases by chemical company Carolina Biological Supply of Burlington, N.C., and shipping company Con-way Freight on Feb. 1, 2011. The chemical company reported a $435 suspicious purchase to the FBI, while the shipping company notified Lubbock police and the FBI because it appeared the order wasn't intended for commercial use.

Court records show that Aldawsari had successfully ordered 30 liters of nitric acid and three gallons of concentrated sulfuric acid in December 2010.

Aldawsari also kept a handwritten journal, in Arabic, in which he said he had been planning a terror attack in the U.S. for years, even before he came to the country on a scholarship, and that it was "time for jihad," or holy war, according to court documents. He bemoaned the plight of Muslims and said he was influenced by Osama bin Laden's speeches.

U.S. District Judge Donald E. Walter ruled last week that prosecutors can use footage from videos found on Aldawsari's computer, including one in which Ayman al-Zawahri, al-Qaida's current leader, praises as martyrs two unspecified individuals killed by "American Crusaders." Two instructional videos that he also allowed show how to prepare the explosive picric acid and how to use a cellphone as a remote detonator.

TNP, the chemical explosive Aldawsari was suspected of trying to make, has about the same destructive power as TNT. FBI bomb experts said the amounts in the Aldawsari case would have yielded almost 15 pounds of explosive ? about the same amount used per bomb in the London subway attacks that killed scores of people in July 2005.

Aldawsari came to the U.S. in October 2008 from Riyadh, Saudi Arabia, to study chemical engineering at Texas Tech. He transferred in early 2011 to nearby South Plains College, where he was studying business. A Saudi industrial company, which was not identified in court documents, was paying his tuition and living expenses.

During jury selection Thursday, Aldawsari's attorney, Dan Cogdell, asked potential panelists if they would have any issue with Aldawsari's Muslim faith or Saudi citizenship. Cogdell also asked if they would "think kind of hard about" sitting next to a Saudi citizen on an airplane.

Aldawsari sat next to his attorneys wearing a dark blue suit jacket and silver tie, and sporting hair that was shorter than during his previous court appearances.

Associated Press

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Syrian government accuses rebels of mass killing

BEIRUT (AP) ? An online video showed more than a dozen bloodied corpses, some of them piled atop each other and in military uniforms, dumped beside a road in northern Syria in what the government Friday called a mass killing by rebel forces.

The circumstances of the deaths were not immediately clear, with the state-run news agency saying at least 25 men were killed. In the video ? which The Associated Press could not independently verify ? the narrator said the victims were members of the "shabiha," or pro-regime gunmen.

If confirmed, the video is yet another sign of the brutality of the Syrian conflict, which began in March 2011. As the fighting grinds on, Syria is descending into a civil war where gunmen prowl the streets and gruesome massacres are growing increasingly common.

The government has used heavy weapons and unleashed snipers and loyalist fighters, but rebels, too, have been accused of bloody attacks.

Civilians have been caught in the crossfire; activists estimate that more than 14,000 people have been killed since the start of the uprising against President Bashar Assad's regime.

In a desperate bid to end the violence after an earlier peace plan failed to do so, U.N. envoy Kofi Annan said that Iran ? one of Syria's most loyal allies ? should be part of the solution to the conflict.

Syria's state-run news agency, SANA, said the dead found in the rebel-held area of Daret Azzeh near Aleppo were killed and their bodies mutilated by terrorist groups. The government refers to rebels as terrorists.

The amateur video showing the corpses appeared to back up the allegation of a mass killing.

"The terrorist groups in Daret Azzeh committed a brutal massacre against the citizens, whom they had kidnapped earlier in the day," SANA said.

The report said at least 25 people were killed, but others were missing.

It was not clear whether the men were killed execution-style or died in clashes. An activist in the area, Mohammed Saeed, said rebels regularly collect the bodies of the dead from the government side and dump them by the side of the road so troops can collect them later.

The city of Aleppo, Syria's largest, has been relatively quiet, but towns and villages around it have seen intense clashes. Daret Azzeh has endured withering government shelling in the past two weeks as Assad's forces try to regain areas taken by rebels. The violence continued Friday, as Syrian troops shelled the area and used helicopter gunships in their attacks on rebels, Saeed said.

"The army has been trying to push through for days without success," Saeed said.

Government troops have been launching a major offensive on many areas throughout the country in the past two weeks to try to regain ground captured by the opposition. Attacks have mostly concentrated on Aleppo, the suburbs of the capital of Damascus, the central province of Homs, the southern region of Daraa and the eastern city of Deir el-Zour.

Activists reported that thousands of people demonstrated against the regime following Friday prayers in different parts of Syria, including Daraa, Aleppo, the northeastern region of Hassakeh and Damascus. The Britain-based Syrian Observatory for Human Rights said troops opened fire at protesters in Aleppo and the Damascus neighborhood of Mazzeh. Several casualties were reported.

The Syrian uprising began with regular anti-regime protests, although they have lost momentum as the revolt turned into an armed insurgency.

An international crisis meeting on Syria set for June 30 is in disarray over the involvement of Iran. The United States has vehemently opposed the participation of Iran, which Russia is demanding.

"I have made it quite clear that I believe Iran should be part of the solution," said Annan, the joint U.N.-Arab League envoy to Syria.

Annan told reporters in Geneva it was "time for countries of influence to raise the level of pressure on the parties on the ground." However, he had no specific proposals for changing his six-point peace plan, which he said Syria had not yet implemented but still might support.

"The longer we wait, the darker Syria's future becomes," said Annan, flanked by Maj. Gen. Robert Mood, the head of the struggling U.N. observer mission in Syria.

Western powers are clinging to the Annan plan, in part because there are no other clear options. There is little support for military intervention of the type that helped bring down Libya's Moammar Gadhafi during a 2011 uprising in that country, and several rounds of sanctions and other attempts to isolate Assad have done little to stop the bloodshed.

Mood praised the work of his 300 U.N. monitors, whose mandate ends next month. He conceded, however, that they are now largely confined to bureaucratic tasks and calling Syrians by phone because of dangers on the ground.

"Their commitment to the Syrian people has not faltered," he said. "Whether more observers or arming observers would be relevant to the situation on the ground, I'm far from convinced that that would help the situation on the ground."

The failure of Annan's peace plan has made it more difficult for outside observers, humanitarian workers and supplies to get in, or reliable information to filter out. Syria restricts the movement of journalists, making it hard to confirm accounts from either side.

Also Friday, the Observatory said four senior army officers have defected from the regime. The group provided a video purporting to show two brigadier generals and two colonels who declared they were joining the opposition.

The group said the defections came Thursday ? the same day a Syrian fighter pilot flew his MiG-21 warplane to neighboring Jordan, where he was given asylum.

Thousands of soldiers have abandoned the regime, but most are low-level conscripts. The Free Syria Army, the loosely linked group of rebel forces, is made up largely of defectors.

A Turkish warplane went down in Syrian waters on Friday, but Turkey's prime minister said he said he had no "definite information" about whether it was shot down by Syrian forces.

"I cannot say it was downed, without definite information. It is not possible to say that," Prime Minister Recep Tayyip Erdogan said at a news conference.

Media reports said Syrian forces downed the plane and apologized.

___

AP writers Elizabeth A. Kennedy in Beirut, Selcan Hacaoglu in Ankarak, Turkey, and John Heilprin in Geneva contributed to this report.

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