শনিবার, ১৯ অক্টোবর, ২০১৩

Mayim Bialik Sues Over Car Accident -- I Nearly Lost a Hand!


Mayim Bialik
Sues Over Car Accident
I Nearly Lost a Hand!



Exclusive


1018_mayim-bialik_tmz

"Big Bang Theory" actress Mayim Bialik has just sued over her serious car accident last year -- claiming it nearly cost her a hand.

As we reported, Bialik was driving in her white Volvo last August when it was struck by a 2013 Mustang in a Hollywood intersection. The other car was filled with Chilean tourists.

At the time, a source told us there was blood everywhere at the crash scene, stemming from major damage to Mayim's hand. Another source said "her finger was almost completely severed ... it was just hanging there."

Now the former "Blossom" star has filed a lawsuit against the other driver as well as Hertz Rent-a-Car -- presumably because the other car was a rental -- claiming she suffered injuries to her right hand, right thumb, and nerve damage.

She's suing for unspecified damages, but that includes lost wages -- and since she earns a reported 5 figures per episode on "Big Bang," it could really add up.

0815-mayim-bailik-article-car-accident-scene-tmz-3





Source: http://www.tmz.com/2013/10/18/mayim-bialik-lawsuit-car-accident-hand-injury/
Related Topics: cory booker   Cameron Bay   legend of korra   college football   Gold Cup final  

শুক্রবার, ১৮ অক্টোবর, ২০১৩

How 'phenotype switching' can make melanoma become metastatic and resistant to drugs

How 'phenotype switching' can make melanoma become metastatic and resistant to drugs


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PUBLIC RELEASE DATE:

18-Oct-2013



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Contact: Ben Leach
bleach@wistar.org
215-495-6800
The Wistar Institute



By understanding the Wnt5A signaling pathway, researchers may be able to determine which patients may respond more favorably to BRAF inhibitors





One of the challenges of understanding cancer is trying to determine the mechanisms that drive metastasis, or the process by which tumor cells are able to spread throughout the body. In order to investigate metastasis, researchers at The Wistar Institute focused on a process involving the phenotypes the outward, physical appearance based on genetic coding of tumor cells. According to the researchers, "phenotype switching" may be involved in changing appearance of melanoma tumors by altering the number and type of protein receptors that dot the surface of the individual melanoma cells within the tumor. Identifying the phenotype patients exhibit may help determine which patients are more likely to benefit from existing medications while also providing an opportunity to create new targeted therapies.


The findings were published in the journal Cancer Discovery and are currently available online.


"We were able to demonstrate for the first time that different receptors within a single signaling pathway in this case, the Wnt signaling pathway can guide the phenotypic plasticity of tumor cells, and increased signaling of Wnt5A in particular can result in an increase in highly invasive tumor cells that are less sensitive to existing treatments for metastatic melanoma," said Ashani Weeraratna, Ph.D., assistant professor in the Tumor Microenvironment and Metastasis Program of Wistar's NCI-designated Cancer Center, and senior corresponding author on the manuscript.


While melanoma accounts for less than 5 percent of all cases of skin cancer, it is the deadliest form of the disease, resulting in a large majority of all the deaths related to skin cancer, according to the American Cancer Society. The five-year survival rate for patients with metastatic melanoma is between 15 and 20 percent, and while new, targeted therapies designed to combat the disease based on a person's genetics have become available in recent years, some of these drugs are not particularly effective in many patients, and many who do respond well to the drugs often eventually become resistant to them. This makes understanding advanced stages of melanoma and what internal processes could be at work all the more important for developing new treatments.

Weeraratna and her team focus on Wnt5A, a Wnt signaling molecule that has been found in increased levels in metastatic melanomas. In order for Wnt5A to promote the phenotype switch from early in the tumor's formation to the time it becomes metastatic, the tyrosine kinase receptor ROR2 is required. When ROR2 is not present, Wnt5A is unable to promote tumor metastasis. The only other member of the family that has been identified is ROR1, and this research was done to determine what role ROR1 might play in the progression of melanoma.

The researchers were able to determine that ROR1 inhibited the invasion of melanoma cells, and this receptor was targeted for degradation by Wnt5A and ROR2. When ROR1 was silenced, the researchers observed that there was an increased rate of invasion of melanoma cells both in vitro and in vivo. The researchers also found that hypoxia areas of low oxygen supply in the tumor is able to induce a switch from ROR1 to ROR2 and results in an increase in levels of Wnt5A, suggesting the switch from a non-invasive ROR1-positive phenotype to an invasive ROR2-positive phenotype occurs when the tumor is exposed to hypoxic conditions. The researchers also found that a protein HIF1α is required to increase the Wnt5A expressed. When HIF1α was removed, ROR2 was decreased, indicating that the upregulation of ROR2 via HIF1α requires Wnt5A.

To determine the clinical implications, the researchers hypothesized that melanoma cells driven by the mutant BRAF gene that were also high in Wnt5A might be less sensitive to treatment with vemurafenib, a drug approved by the FDA in 2011 for the treatment of BRAF-positive metastatic melanoma. By measuring BRAF cell lines to determine their Wnt5A and ROR2 status, as well as their sensitivity to BRAF inhibitors, the researchers found a significant correlation between BRAF inhibitor resistance and Wnt5A expression. Additionally, in a small cohort of patients, they found that seven out of nine patients who demonstrated less than a 33 percent clinical response to vemurafenib had a positive expression of Wnt5A, and only two of the remaining 15 patients who had a 38% or greater clinical response to vemurafenib exhibited any Wnt5A expression. When they silenced ROR2 in tumors xenografted in mice, the tumors responded far better to simultaneous treatment with the BRAF inhibitor vemurafenib. Conversely, when ROR1 was silenced, the tumors became more resistant to the drug.

Additionally, in eight patients who had undergone BRAF inhibitor therapy, the levels of Wnt5A were much lower in tumor cells prior to therapy compared to cells that were tested for Wnt5A after those same patients had relapsed.

"By using Wnt5A as a biomarker, we could determine which patients are likely to respond better to therapy with vemurafenib and help prolong that response," Weeraratna said. "There is also the potential to explore small molecule inhibitors of ROR2, since there is now a clear association between that and the ability of melanoma to become not only metastatic, but also therapy-resistant. This link between metastasis and therapy resistance is what we find the most exciting and intriguing, as therapies designed to target one process may have a significant impact on the other as well. "

###

The co-authors of the study are members of the Tumor Metastasis and Microenvironment Program and the Molecular and Cellular Oncogenesis Program at Wistar. They include Michael P. O'Connell,Ph.D.; Katie Marchbank, Ph.D.; Marie R. Webster, Ph.D.; Alexander A. Valiga; Amanpreet Kaur; Adina Vultur, Ph.D.; Ling Li, M.D.; Meenhard Herlyn, D.Vm., D.Sc.; and Sandy Widura in the Tumor Metastasis and Microenvironment Program, and Jessie Villanueva, Ph.D.; Qin Liu, M.D., Ph.D.; and Xiangfan Yin in the Molecular Cellular Oncogenesis Program. O'Connell is the lead author of the study. The researchers also collaborated with the National Institute on Aging of the National Institutes of Health; Dana Farber/Harvard Cancer Center; the Lehigh Valley Health Network; and the Abramson Cancer Center of the University of Pennsylvania.

This study was made possible in part by grants from the National Institute on Aging Intramural Research Program, the PA Department of Health (CURE) funding, and the Joanna M. Nicolay Foundation.




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How 'phenotype switching' can make melanoma become metastatic and resistant to drugs


[ Back to EurekAlert! ]

PUBLIC RELEASE DATE:

18-Oct-2013



[


| E-mail



| Share Share

]

Contact: Ben Leach
bleach@wistar.org
215-495-6800
The Wistar Institute



By understanding the Wnt5A signaling pathway, researchers may be able to determine which patients may respond more favorably to BRAF inhibitors





One of the challenges of understanding cancer is trying to determine the mechanisms that drive metastasis, or the process by which tumor cells are able to spread throughout the body. In order to investigate metastasis, researchers at The Wistar Institute focused on a process involving the phenotypes the outward, physical appearance based on genetic coding of tumor cells. According to the researchers, "phenotype switching" may be involved in changing appearance of melanoma tumors by altering the number and type of protein receptors that dot the surface of the individual melanoma cells within the tumor. Identifying the phenotype patients exhibit may help determine which patients are more likely to benefit from existing medications while also providing an opportunity to create new targeted therapies.


The findings were published in the journal Cancer Discovery and are currently available online.


"We were able to demonstrate for the first time that different receptors within a single signaling pathway in this case, the Wnt signaling pathway can guide the phenotypic plasticity of tumor cells, and increased signaling of Wnt5A in particular can result in an increase in highly invasive tumor cells that are less sensitive to existing treatments for metastatic melanoma," said Ashani Weeraratna, Ph.D., assistant professor in the Tumor Microenvironment and Metastasis Program of Wistar's NCI-designated Cancer Center, and senior corresponding author on the manuscript.


While melanoma accounts for less than 5 percent of all cases of skin cancer, it is the deadliest form of the disease, resulting in a large majority of all the deaths related to skin cancer, according to the American Cancer Society. The five-year survival rate for patients with metastatic melanoma is between 15 and 20 percent, and while new, targeted therapies designed to combat the disease based on a person's genetics have become available in recent years, some of these drugs are not particularly effective in many patients, and many who do respond well to the drugs often eventually become resistant to them. This makes understanding advanced stages of melanoma and what internal processes could be at work all the more important for developing new treatments.

Weeraratna and her team focus on Wnt5A, a Wnt signaling molecule that has been found in increased levels in metastatic melanomas. In order for Wnt5A to promote the phenotype switch from early in the tumor's formation to the time it becomes metastatic, the tyrosine kinase receptor ROR2 is required. When ROR2 is not present, Wnt5A is unable to promote tumor metastasis. The only other member of the family that has been identified is ROR1, and this research was done to determine what role ROR1 might play in the progression of melanoma.

The researchers were able to determine that ROR1 inhibited the invasion of melanoma cells, and this receptor was targeted for degradation by Wnt5A and ROR2. When ROR1 was silenced, the researchers observed that there was an increased rate of invasion of melanoma cells both in vitro and in vivo. The researchers also found that hypoxia areas of low oxygen supply in the tumor is able to induce a switch from ROR1 to ROR2 and results in an increase in levels of Wnt5A, suggesting the switch from a non-invasive ROR1-positive phenotype to an invasive ROR2-positive phenotype occurs when the tumor is exposed to hypoxic conditions. The researchers also found that a protein HIF1α is required to increase the Wnt5A expressed. When HIF1α was removed, ROR2 was decreased, indicating that the upregulation of ROR2 via HIF1α requires Wnt5A.

To determine the clinical implications, the researchers hypothesized that melanoma cells driven by the mutant BRAF gene that were also high in Wnt5A might be less sensitive to treatment with vemurafenib, a drug approved by the FDA in 2011 for the treatment of BRAF-positive metastatic melanoma. By measuring BRAF cell lines to determine their Wnt5A and ROR2 status, as well as their sensitivity to BRAF inhibitors, the researchers found a significant correlation between BRAF inhibitor resistance and Wnt5A expression. Additionally, in a small cohort of patients, they found that seven out of nine patients who demonstrated less than a 33 percent clinical response to vemurafenib had a positive expression of Wnt5A, and only two of the remaining 15 patients who had a 38% or greater clinical response to vemurafenib exhibited any Wnt5A expression. When they silenced ROR2 in tumors xenografted in mice, the tumors responded far better to simultaneous treatment with the BRAF inhibitor vemurafenib. Conversely, when ROR1 was silenced, the tumors became more resistant to the drug.

Additionally, in eight patients who had undergone BRAF inhibitor therapy, the levels of Wnt5A were much lower in tumor cells prior to therapy compared to cells that were tested for Wnt5A after those same patients had relapsed.

"By using Wnt5A as a biomarker, we could determine which patients are likely to respond better to therapy with vemurafenib and help prolong that response," Weeraratna said. "There is also the potential to explore small molecule inhibitors of ROR2, since there is now a clear association between that and the ability of melanoma to become not only metastatic, but also therapy-resistant. This link between metastasis and therapy resistance is what we find the most exciting and intriguing, as therapies designed to target one process may have a significant impact on the other as well. "

###

The co-authors of the study are members of the Tumor Metastasis and Microenvironment Program and the Molecular and Cellular Oncogenesis Program at Wistar. They include Michael P. O'Connell,Ph.D.; Katie Marchbank, Ph.D.; Marie R. Webster, Ph.D.; Alexander A. Valiga; Amanpreet Kaur; Adina Vultur, Ph.D.; Ling Li, M.D.; Meenhard Herlyn, D.Vm., D.Sc.; and Sandy Widura in the Tumor Metastasis and Microenvironment Program, and Jessie Villanueva, Ph.D.; Qin Liu, M.D., Ph.D.; and Xiangfan Yin in the Molecular Cellular Oncogenesis Program. O'Connell is the lead author of the study. The researchers also collaborated with the National Institute on Aging of the National Institutes of Health; Dana Farber/Harvard Cancer Center; the Lehigh Valley Health Network; and the Abramson Cancer Center of the University of Pennsylvania.

This study was made possible in part by grants from the National Institute on Aging Intramural Research Program, the PA Department of Health (CURE) funding, and the Joanna M. Nicolay Foundation.




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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.




Source: http://www.eurekalert.org/pub_releases/2013-10/twi-hs101813.php
Category: elizabeth olsen   tesla model s   Lisa Robin Kelly   Amish Mafia   mick jagger  

'Yeah, Baby!': Local News Anchors React to Mike Myers' Baby News (Video)



New Line Cinema/Courtesy Everett Collection



Bring on the baby puns.



A rep for Mike Myers announced earlier this week that he and wife Kelly Tisdale are expecting their second child, prompting an avalanche of -- what else? -- Austin Powers jokes.


PHOTOS: 33 Power Canadians in Hollywood


On Thursday, Conan aired a minute-and-a-half-long sizzle reel featuring local news anchors delivering the news, and the variety was scant.


Watch below to see newspeople across the country relay: "Mike Myers says, 'Yeah, baby!' " nearly 30 times.


Myers and Tisdale, who married in 2010, are already parents to 2-year-old Spike.



Source: http://feedproxy.google.com/~r/thr/television/~3/GyAFgH9WaPM/story01.htm
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What Does The Rise Of Super-Fortunes Mean For The Rest Of Us?






For the first time in history, if you are an energetic entrepreneur with a brilliant new idea or a fantastic new product ... you can get very, very rich, very, very quickly.





Part 2 of the TED Radio Hour episode Haves And Have-Nots.


About Chrystia Freeland's TEDTalk


Author and politician Chrystia Freeland says economic inequality is growing by leaps and bounds. She charts the rise of today's billionaire plutocrats and wonders what the concentration of wealth means for the rest of us.


About Chrystia Freeland


In her book, Plutocrats: The Rise Of The New Global Super-Rich And The Fall Of Everyone Else, Chrystia Freeland looks under the hood of global capitalism to explain the technological, economic and structural inequalities pushing society in unforeseen directions.


Along the way, she takes the temperature of a growing caste of super-rich billionaires and shows how the creation of vast fortunes at the top hollow out the middle class in Western industrialized countries.


Freeland began her career as an "accidental journalist" with front-line bulletins from the Ukraine in the heat of the Soviet collapse. She recently left her post as managing director and editor at Thomson Reuters. She's now running for office with the center-left Liberal Party of Canada.


Source: http://www.npr.org/2013/10/18/235791324/what-does-the-rise-of-super-fortunes-mean-for-the-rest-of-us?ft=1&f=1019
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'Project Runway' Season 12 Winner Revealed



[Warning: Spoilers ahead if you haven't seen the season 12 finale of Project Runway.]



Project Runway has revealed its latest winner.


Dom Streater beat out Alexandria von Bromssen, Bradon McDonald and Justin LeBlanc to take home the season 12 crown in Thursday night's finale of the Lifetime fashion-design completion.


PHOTOS: 'Project Runway' Winners: Where Are They Now?


The 24-year-old from Philadelphia presented a "Retro Redux" collection during New York Fashion Week. Judges Heidi Klum, Nina Garcia and Zac Posen, along with guest judge Kerry Washington, decided the winner. Von Bromssen came in second, while LeBlanc was in third.


As winner of Season 12, Streater won a prize package worth more than a half-million dollars, including a 2014 Lexus IS 350; $150,000 from GoBank; $50,000 of next-generation technology from HP and Intel; a year’s supply of Natural Spring Water; a spa retreat for two to the Maldives; a chance to design and sell an exclusive collection at Belk; a complete sewing and crafting studio from Brother Sewing and Embroidery; a fashion spread in Marie Claire magazine; a $100,000 fabric allowance from Tide Pods; and a $50,000 styling contract with L'Oréal Paris. 


PHOTOS: 'Project Runway' Season 12: Meet the Designers


Streater’s model, Rayuana Aleyce, will receive a fashion spread in Marie Claire and $25,000 from L'Oréal Paris.


Check back Friday for THR's interview with Streater.



Source: http://feedproxy.google.com/~r/live_feed/~3/nNurLNDNYEA/story01.htm
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Character Actor Ed Lauter Dies At Age 74





Actor Ed Lauter attends the world premiere of The Tourist at the Ziegfeld Theatre in 2010 in New York.



Evan Agostini/AP


Actor Ed Lauter attends the world premiere of The Tourist at the Ziegfeld Theatre in 2010 in New York.


Evan Agostini/AP


Veteran character actor Ed Lauter's long, angular face and stern bearing made him an instantly recognizable figure in scores of movies and TV shows.


His career stretched across five decades. He was 74.


Lauter's publicist, Edward Lozzi, says the actor died Wednesday of mesothelioma, a rare form of cancer most commonly caused by asbestos exposure.


Lauter's presence as an irascible authority figure, a brutal thug or a conniving con man made him all but impossible to miss in any film he was in.


He was the brutal prison guard who was Burt Reynolds' nemesis in the 1974 comedy-drama The Longest Yard and the sleazy gas station attendant in Alfred Hitchcock's last film, The Family Plot.


His TV appearances included The Office, ER, Murder, She Wrote and The Rockford Files.


Source: http://www.npr.org/2013/10/17/236001358/character-actor-ed-lauter-dies-at-age-74?ft=1&f=1048
Tags: Tony Gonzalez   2013 Emmy Winners   Kerry Washington   Dufnering   Jennifer Rosoff  

Obama lashes Republicans as government reopens

National Park Service employees remove barricades from the grounds of the Lincoln Memorial in Washington, Thursday, Oct. 17, 2013. Barriers went down at National Park Service sites and thousands of furloughed federal workers began returning to work throughout the country Thursday after 16 days off the job because of the partial government shutdown.(AP Photo/Susan Walsh)







National Park Service employees remove barricades from the grounds of the Lincoln Memorial in Washington, Thursday, Oct. 17, 2013. Barriers went down at National Park Service sites and thousands of furloughed federal workers began returning to work throughout the country Thursday after 16 days off the job because of the partial government shutdown.(AP Photo/Susan Walsh)







President Barack Obama speaks in the State Dining Room of the White House in Washington on Thursday, Oct. 17, 2013. Lawmakers Wednesday voted to avoid a financial default and reopen the government after a 16-day partial shutdown. (AP Photo/Jacquelyn Martin)







Passengers fill up Washington Metro subway cars in Arlington, Va., Thursday, Oct. 17, 2013 as workers return to their jobs after a budget fight on Capitol Hill that resulted in a partial government shutdown is resolved. (AP Photo/J. David Ake)







An audience comprising of White House staff members, stands as President Barack Obama leaves the State Dining Room of the White House in Washington, Thursday, Oct. 17, 2013, after he made a statement. Lawmakers Wednesday voted to avoid a financial default and reopen the government after a 16-day partial shutdown. (AP Photo/Charles Dharapak)







President Barack Obama speaks in the State Dining Room of the White House in Washington, Thursday, Oct. 17, 2013. Lawmakers Wednesday voted to avoid a financial default and reopen the government after a 16-day partial shutdown. (AP Photo/Charles Dharapak)







WASHINGTON (AP) — In withering day-after criticism, President Barack Obama declared Thursday that the 16-day partial government shutdown was a Republican-provoked spectacle that "encouraged our enemies" around the world.

Elsewhere in Washington, and around the country, federal employees simply streamed back to their jobs. National parks reopened. The popular panda cam at the National Zoo came back online.

But there was no letup in the political fight.

Fresh from a defeat, tea party groups and their allies renewed fundraising efforts with a promise of future assaults on Obama's health care overhaul — and a threat of more election primaries against Republican incumbents who don't stand with them.

Government spending was still front and center. Inside the Capitol, lawmakers charged with forging a post-shutdown deficit-cutting agreement in the next 60 days met privately. "We believe there is common ground," said Sen. Patty Murray, D-Wash., chair of the Senate Budget Committee.

Privately, however, officials in both parties said the prospects for a major breakthrough were dim, given differences over taxes and spending that have proven compromise-proof throughout the current three-year era of divided government.

A few hours after Obama placed his post-midnight signature on legislation ending the long political showdown, Vice President Joe Biden was at the Environmental Protection Agency to greet returning employees. "I hope this is the end of this," he said, but he acknowledged "There's no guarantees."

That was a reference to the last-minute legislation that will fund the government only until Jan 15 and give Treasury the ability to borrow above the $16.7 trillion limit until Feb. 7 or a few weeks longer.

At the White House, Obama blended sharp criticism of Republicans with a plea for their cooperation over the remainder of the year and a call for less shrillness on both sides.

"Some of the same folks who pushed for the shutdown and threatened default claimed their actions were needed to get America back on track," he said in remarks in the State Dining Room.

"But probably nothing has done more damage to America's credibility to the world. ... It's encouraged our enemies. It's emboldened our competitors. And it's depressed our friends who look to us for steady leadership," he said.

Obama said the public is "completely fed up with Washington" and he and Congress face hard work in regaining trust. It was a reference to public opinion polls that show the nation in a sour mood — though more inclined to blame Republicans than the president and his party for the first partial government shutdown caused by politics in 17 years.

Hoping to jump-start his own stalled agenda, Obama urged lawmakers to concentrate on three items in the coming weeks: a balanced plan to reduce long-term deficits, legislation to overhaul the immigration system and passage of a farm bill.

Polling aside, Obama's party emerged from the three-week showdown in Congress united. All Democrats in Congress supported the legislation that passed Wednesday night to fund the government and raise the debt limit.

Not so of the Republicans. Eighteen GOP members in the Senate and 144 in the House opposed the legislation, while 27 in the Senate and 87 in the House supported it.

The fault line separated tea party adherents from the balance of the rank and file. And there were clear signs the split was enduring, though not widening.

In Mississippi, where GOP Sen. Thad Cochran has not yet announced if he will seek a new term in 2014, the Club for Growth and Senate Conservatives Fund were not waiting to find out. They endorsed a potential rival, Republican state Sen. Chris McDaniel, as he announced his candidacy.

The groups are among several that have played an increasingly active role in Republican primary elections in recent years, several times supporting tea party-aligned challengers. In some cases — Sen. Ted Cruz of Texas, for one — they went on to victory in the fall. In more, they lost seemingly winnable races to Democrats.

One survivor of such a challenge, Sen. Orrin Hatch, R-Utah, said during the day that the Heritage Foundation is in danger of losing its clout as a reliable conservative think tank because of the actions of its political arm, Heritage Action.

In an interview on MSNBC, he said, "There's a real question in the minds of many Republicans now. ... Is Heritage going to go so political that it really doesn't amount to anything anymore?"

Heritage Action played an influential role in the two-week political showdown. In the days leading to the impasse, it was a strong backer of the campaign to demand that "Obamacare" be defunded in exchange for Republican approval of funding for the government.

And on Tuesday, as it was hosting a fundraiser at a high-end golf resort in Bandon, Ore., the group weighed in to oppose legislation that House Speaker John Boehner put together in hopes of retaining influence in the final negotiations over the impasse in Washington.

Yet another group, Americans for Limited Government, assailed Rep. Scott Rigell, R-Va., who voted for the legislation that reopened the government and raised the debt limit. Noting that the measure had not defunded the health care law, the group said the congressman "owns Obamacare just as much as if it had been a vote to adopt it in the first place."

In a statement issued on Wednesday in connection with his vote, Rigell said he was voting for the bill "given the lack of a viable alternative at this moment."

Other Republicans have said for weeks that the strategy of demanding Obama kill off the health care law he won from Congress never had a chance of success.

"This was a terrible idea," Sen. John McCain of Arizona said on CNN of the shutdown. He said it will not happen again when the next deadlines arrive — "I guarantee it."

But in a party divided, there were dissenters.

"Obamacare is still fully intact, out-of-control spending continues, the debt limit is raised without addressing unsustainable spending, and only vague promises are left to address these key issues," the Tea Party Express said in an online fundraising appeal.

Referring to next year's elections, the group said, "To put it plain and simple: We don't have enough conservatives in Congress to stop the irresponsible spending in Washington."

Spending will be the focus for the high-level budget negotiators who began their new assignment Thursday.

"Talking doesn't guarantee success," said Rep. Chris Van Hollen of Maryland, senior Democrat on the House Budget Committee, after he met with Democratic Sen. Murray, Republican House Budget Chairman Paul Ryan of Wisconsin and Alabama Sen. Jeff Sessions, senior Republican on the Senate committee. But, Van Hollen added, "if you don't get together, obviously you don't move forward."

___

Associated Press writer Alan Fram contributed to this story.

Associated PressSource: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-10-17-Budget%20Battle/id-5c9daf4a0f4f47de88f3816474e940d3
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